Senior MSL

Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.

Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder.

Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.

Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders.

By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future.

Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.

Together we are moving psychiatry forward—beyond better, into a boundless future.

Join us!

The Senior Medical Science Liaison (MSL) will serve as a field-based scientific and clinical expert for our psychiatry portfolio, building and maintaining strong relationships with Key Opinion Leaders (KOLs), healthcare providers, policy influencers, and other stakeholders. This role will focus on engaging the medical community to communicate scientific data, provide clinical insights, and ensure that our research and development efforts align with real-world practice needs. Additionally, this role will also help shape internal resources, training, and capabilities for the broader Field Medical Function The ideal candidate will have a deep understanding of psychiatric disorders, a passion for science-driven conversations, and the ability to operate effectively in a small, fast-growing biotech environment.

Identify, develop and maintain trusted relationships with KOLs, clinical investigators, and key stakeholders across academic and clinical psychiatry

Serve as point person as needed with Government Affairs and HEOR to provide scientific and clinical expertise in policy discussions, public comment submissions, and stakeholder briefings
Support Government Affairs and Patient Advocacy in identifying and maintaining relationships with relevant government agencies, policymakers, and advocacy groups in mental health and psychiatry
Oversee creation of specific slide decks and training materials for state and federal government policymakers
Collaborate with internal teams to develop educational materials for HEOR and advocacy organizations
As requested, represent the company at government affairs forums, mental health advocacy events, and policy-related conferences

Partner with leadership to develop core training programs for future MSL onboarding, disease state fluency, and scientific platform mastery
Contribute to the design of field materials, medical decks, and engagement resources (e.g., CRM design)
Assist in establishing best practices for field insights capture, CRM documentation, and KOL engagement

Advanced scientific degree (PharmD, PhD, MD, or equivalent) strongly preferred
Minimum of 5+ years of MSL or related medical affairs experience; psychiatry/CNS experience required
Record of successfully supporting pre-launch through launch staged companies with an entrepreneurial mindset
Experience engaging with policy, government affairs, or advocacy stakeholders in the healthcare sector strongly preferred
Deep understanding of psychiatric disease states, treatment paradigms, and the U.S. healthcare landscape
Strong presentation, communication, and interpersonal skills
Ability to interpret and present complex scientific data in a clear and concise manner
Familiarity with CRM systems, insight tools, and compliant field operations
Comfortable working in a high-growth, fast-paced biotech environment with cross-functional collaboration
Willingness to travel up to 60% as needed

The starting base pay range for this position is $225,560.00 - $255,000.00.

will be determined based on several factors including, but not limited to, skill set, years of experience, and the employee’s geographic location.

Employees in this role may be entitled to additional compensation, including bonus and equity.

information is listed on our Jobs Page.

The Company provides competitive benefits to employees including:

100% paid health benefits including Medical, Dental and Vision for you and your dependents
401(k) program with company match and vesting after the turn of the first month after your start date
Flexible time off
Generous parental leave and some fun fringe perks!

Senior MSL - Mid West(Multiple Territories)

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