Scientist, Computational Chemist & MLOps Engineer

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them.

Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes.

RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein.

Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease.

The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics.

Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI.

Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

We are seeking a highly motivated computational scientist to join our research organization and contribute to machine learning–driven drug discovery efforts.

This role will focus on data engineering, statistical modeling, bioinformatics, and scientific software development supporting internal therapeutic design programs.

The ideal candidate combines strong quantitative reasoning with practical software engineering skills and is comfortable operating independently in a Linux-based research computing environment.

This position may be filled at the Scientist I - III level depending on experience and qualifications.