Scientist / Associate Scientist – Preclinical Design & Development (PDD) Core

Preferred Qualifications and Attributes

• Experience with plate-based molecular screening workflows and quantitative nucleic acid assays (RT-qPCR, ddPCR); familiarity with isoform-discriminating or allele-specific probe design is preferred.
• Working knowledge of RNA biology, particularly pre-mRNA splicing, and comfort interpreting molecular readouts in a therapeutic context.
• Proficiency in mammalian cell culture, including complex or patient-derived cellular models.
• Ability to manage and execute multi-step experimental workflows across parallel projects with consistency and rigor.
• Comfort adapting established protocols to new cellular contexts and working through scientific uncertainty iteratively.
• Team-first orientation and comfort with flexible, pipeline-driven translational work.

What You Will Do

• Design and execute cell-based therapeutic evaluation workflows and validation pipelines with high rigor across concurrent patient cases.
• Derive, characterize, and bank patient-specific cellular models to enable screening and functional validation.
• Design and validate quantitative molecular assays (RT-qPCR, ddPCR) and perform biochemical and imaging-based readouts to evaluate therapeutic efficacy.
• Manage parallel experimental timelines and maintain proactive communication with collaborating teams to support project objectives.
• Maintain rigorous documentation, data integrity, and quality control standards consistent with a Core laboratory environment.
• Support monitoring and stocking of supplies; calibration, maintenance, or troubleshooting of equipment.
• Contribute positively to a culture of shared responsibility, mutual support, and collective scientific progress.
• Perform other duties as assigned in support of Core and departmental objectives.

Minimum Education and/or Training

Scientist Minimum Experience

Associate Scientist Minimum Experience

Compensation

• Explore our exceptional benefits !
• We are committed to a human-centered hiring experience. Technology may support portions of our process, but recruiting decisions involve human review and engagement. Learn more about our approach to AI .
• St. Jude is an Equal Opportunity Employer

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