Scale-up Process Engineer

We are hiring multiple Scale-Up Process Engineers to support a new facility and research program.

The team will develop and test the processes and equipment needed to scale up a new biobased chromatography process.

Over the next two years, the program will focus on producing active materials at scale and demonstrating an automated pilot-plant process capable of producing 10 kg of material per week.

This position offers a hybrid schedule, blending in-person and virtual presence.

You will have the flexibility to work from home one or more days per week.

This position will be filled at either level based on knowledge and related experience as assessed by the hiring team.

Additional job responsibilities (outlined below) will be assigned if hired at the higher level.

You will

• Gather, develop, and interpret process engineering requirements; conduct experiments; and develop and interpret technical design drawings to understand the manufacturing, design, and operational requirements for new pilot systems.
• Perform engineering calculations and sizing estimates to determine the appropriate materials, volumes, chemical compatibility, dimensions, and functionality required for successful operation of custom pilot units.
• Lead data collection and recommend appropriate equipment, instrumentation, vendors, and modeling or simulation approaches to support successful pilot-plant operations.
• Prepare technical documentation; trend performance, yield, and purity data; and perform root-cause analyses to validate pilot-unit performance and identify potential issues in the chromatography process. Apply knowledge of materials, bioengineering, manufacturing, and process controls and monitoring to resolve issues efficiently.
• Provide input on resolving technical issues and support continued technology development for future research and development projects.
• Communicate effectively and thrive in a multidisciplinary environment with an accelerated project schedule and challenging milestones and deliverables.
• Perform other duties as assigned.

Additional job responsibilities, at the SES.3 level

• Lead day-to-day laboratory activities for the installation, setup, and operation of multiple custom laboratory- and pilot-scale chromatography column platforms, including motion systems, tooling, sensors, analytical equipment, and automation and process controls. Ensure accurate and repeatable process setup, material balances, and monitoring to support successful product production.
• Work within a multidisciplinary team of stakeholders, including designers, engineers, analysts, chemists, materials scientists, technicians, subcontractors, and manufacturers, to complete scale-up activities in alignment with program and sponsor leadership.
• Maintain troubleshooting, maintenance, process, procedure, test-unit, and pilot-plant documentation, and recommend and implement improvements.
• Ability to obtain and maintain a U.S.

of Energy (DOE) Q-level security clearance, which requires U.S. citizenship.

• Bachelor’s degree in engineering, chemical engineering, mechanical engineering, or another related engineering specialty, with experience working in laboratory or pilot-plant settings.
• At least two years of experience in chemical process design, process engineering, technology development for industrial applications, or an industry sector such as energy production or chemical manufacturing.
• Expertise in process design, pilot-plant operations, and equipment selection, including familiarity with compressors, pumps, mass flow controllers, solenoid valves, and instrumentation.
• Experience applying industry standards, such as ASME, NFPA, API, cGMP, GDP, and OSHA, to pilot equipment and procedures, as well as experience developing standard operating procedures (SOPs).

Additional qualifications at the SES.3 level

• Project management and leadership experience, including the ability to guide contractors and tradespeople in building custom laboratory and pilot systems on schedule and within budget.
• Master’s or doctoral degree in chemical, mechanical, industrial, or materials engineering, or a related field, or an equivalent combination of education and relevant experience.
• Proficiency with column chromatography, including method development and optimization for chromatographic separations, column packing, equilibration, qualification, solution preparation, system maintenance, and equipment troubleshooting.

$146,340 - $222,564 Annually $146,340 - $185,544 Annually for the SES.2 level $175,530 - $222,564 Annually for the SES.3 level

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting; pay will not be below any applicable local minimum wage.

An employee’s position within the salary range will be based on several factors including, but not limited to, specific competencies, relevant education, qualifications, certifications, experience, skills, seniority, geographic location, performance, and business or organizational needs.

#LI-Hybrid

This is a Career Indefinite position, open to Lab employees and external candidates.

Why Lawrence Livermore National Laboratory?

• Included in 2026 Best Places to Work by Glassdoor!

• 401(k)
• Relocation Assistance

• Flexible schedules (depending on project needs)
• Our values - visit https://www.llnl.gov/inclusion/our-values

This position requires a Department of Energy (DOE) Q-level clearance.

If you are selected, we will initiate a Federal background investigation to determine if you meet eligibility requirements for access to classified information or matter.

Also, all L or Q cleared employees are subject to random drug testing.

Q-level clearance requires U.S. citizenship.

External applicant(s) selected for this position must pass a post-offer, pre-employment drug test.

This includes testing for use of marijuana as Federal Law applies to us as a Federal Contractor.

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