General DiffUSE Job Application

DiffUSE is a project at the Astera Institute building open infrastructure for studying protein dynamics directly from experimental data. We work at the interface of structural biology (crystallography, cryo-EM), modern machine learning, computational biophysics, and open scientific tooling. Our team spans computational biologists, ML researchers, software engineers, and program staff, collaborating across Astera, Radial, and partner institutions.

We are growing, and we want to hear from people who would be excited to join us, even if we have not yet posted the specific role that fits you.

Submit your CV and one paragraph telling us what you can contribute to diffUSE

We review submissions on a rolling basis

If there is a fit now or in the near future, we will reach out

We will only respond if we are interested in exploring further

Diffraction data processing and structural data pipelines

Multiconformer and heterogeneity analysis from large datasets

Data standards work (mmCIF and related)

Macromolecular ensemble metrics

Representation learning for protein dynamics

ML on raw experimental data rather than processed structures

3D vision and geometric deep learning backgrounds especially welcome

Designing and running campaigns to generate large structural datasets