Sr Manager, Industrial Engineering & Process Optimization

Analyze manufacturing line performance data to identify capacity constraints, turnaround time bottlenecks, and labor utilization inefficiencies across production processes

Investigate first pass rate losses and defect trends; lead root cause analysis efforts in partnership with Quality and Manufacturing to reduce rework, scrap, and reprocessing

Develop and prioritize a pipeline of improvement opportunities, evaluating whether process redesign, equipment/automation investment, or staffing changes offer the best return

Build business cases and ROI models for proposed improvements, including capital equipment requests, to support engineering and manufacturing leadership decision-making

Design and implement process changes using industrial engineering tools (time-motion studies, line balancing, value stream mapping, DOE) and validate improvements through structured pilots

Partner with Automation Engineering to scope opportunities where equipment or automation upgrades can address capacity, quality, or labor constraints

Collaborate with Manufacturing and Workforce Planning to right-size staffing models and improve labor efficiency without compromising quality or compliance

Establish and track key performance indicators (OEE, first pass yield, cycle time, cost-per-unit) to measure the impact of improvement initiatives over time

Ensure all process changes are executed in compliance with GxP requirements, working with Quality Assurance on change control and documentation

Present improvement roadmaps, project status, and results to senior engineering and manufacturing leadership

Education: A Bachelor’s or Master’s degree in Industrial Engineering, Mechanical Engineering, Manufacturing Engineering, or a related technical field

8–12+ years of progressive experience in industrial engineering, continuous improvement, or manufacturing process optimization

3–5+ years in a supervisory, management, or cross-functional team leadership role

Demonstrated hands-on experience working within ISO 13485 or GxP-regulated environments.

Strong analytical foundation with expertise in OEE, Cpk, takt time, and cost-per-unit modeling

Proven ability to influence cross-functional stakeholders without direct authority over manufacturing execution

Hands-on expertise using core industrial engineering tools (time-motion studies, line balancing, capacity modeling, and value stream mapping)

Experience working within high-throughput biomanufacturing, biotechnology, or life science manufacturing environments.

Demonstrated track record of leading complex, multi-functional process optimization or automation initiatives from diagnostic to execution.

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.