Senior Scientist - Method Development-Biomarker LC-MS/MS

Title: Senior method development scientist- Biomarker LC-MS/MS

Location: 700 Pennsylvania Dr. Exton, PA

Reports to : SVP, Central Lab, Biomarker, and Biologics Services

Full-time/on-site

Frontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.

Position/Job Summary:

The Senior method development scientist supports method development using LC-MS/MS platform for large molecules (biomarkers, proteins, antibodies, ADCs, Oligonucleotides, etc). The senior method development scientist will be a member of the method development team, the responsibility includes serving as subject matter expert when new proposal is received, reviewing the client request and evaluating the feasibility of the project, developing the method after the contract is signed, transferring the developed method to the validation team, and troubleshooting for challenging method.

Roles & Responsibilities:

Develop method using LC-MS/MS platform for large molecules (Proteins, antibodies, ADC, Oligonucleotides, Liposomal drugs, biomarkers, etc) quantitation in biological matrices.

Facilitate the method transfer from the Method development team with the method validation team.

Communicate project timelines, status, and data to Principal Investigator effectively addressing any issues that may arise.

Ability to work on multiple projects at the same time.

Research literature and external sources and identify new techniques and procedures that strengthen Frontage’s capabilities.

Maintain the proper level of regulatory compliance. Ensure that GLP regulations and SOPs are followed in all bioanalytical service activities.