Senior Scientist, In Vivo Pharmacology
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Key skills for this role
Key Skills for This Role
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Key responsibilities
- Independently design , plan, and lead in vivo pharmacology studies aligned with project objectives .
- Establish, optimize , and evaluate oncology models, including xenograft, syngeneic , and humanized mouse models.
- Perform and oversee mouse procedures, including handling, intravenous dosing, monitoring, tissue collection, and necropsy activities, in accordance with approved protocols.
- Assess vector biodistribution, transduction, transgene expression, pharmacodynamic activity, anti-tumor efficacy, immune responses, and tolerability.
- Design and execute flow cytometry assays, including sample preparation, panel development, controls, data quality assessment, and interpretation.
- Perform or oversee nucleic acid extraction and analysis using techniques such as qPCR or digital PCR to measure viral integration and biodistribution .
- Analyze and integrate complex in vivo , cellular, and molecular data, identifying key conclusions to recommend next steps.
- Maintain accurate and complete study documentation, including protocols, experimental records, sample inventories, data analyses, and study reports.
- Communicate study plans, results, and recommendations clearly to project teams and senior stakeholders.
- Contribute to a collaborative, high-performing team , and support the development of robust and reproducible experimental workflows.
Essential experience and qualifications
- BA/BS with at least 5 years of relevant experience or MA/MS with 3 years' experience or PhD in pharmacology, oncology, immunology, biology, biomedical sciences, or a related discipline.
- Demonstrated hands-on experience with oncology and humanized mouse models.
- Practical experience handling mice and performing procedures such as intravenous administration, tumor monitoring, tissue collection, and necropsy.
- Proven ability to independently lead and deliver well-designed, high-quality in vivo studies.
- Experience with flow cytometry and nucleic acid extraction and analysis from primary in vivo samples .
- Strong data interpretation, problem-solving, and scientific communication skills.
- A strong commitment to data integrity, quality documentation, reproducibility, and animal welfare.
- Ability to work effectively in a fast-paced, matrixed environment and manage multiple priorities.
Desirable experience
Experience in pharmaceutical or biotechnology research, preferably within oncology, gene therapy, viral vectors, or translational pharmacology.
Experience with viral vector platforms, vector biodistribution, transduction, or immunogenicity assessment.
Knowledge of tumor immunology, immune-cell profiling, or the tumor microenvironment.
Experience with translational biomarkers, immunohistochemistry, histopathology, or related bioanalytical techniques.
Experience managing CROs and coordinating activities across internal and external teams.
Experience mentoring colleagues or leading cross-functional scientific workstreams.
When we put unexpected teams in the same room, we fuel bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and daring world.
The annual base pay for this position ranges from $118K to $178K. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.
Closing Date
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
About AstraZeneca
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