Senior Scientist. Cell Therapy Process Development

Education and Experience

Required Skills

• Strong hands-on experience with mammalian cell culture, aseptic processing, and development of cell therapy manufacturing processes.
• Demonstrated ability to design experiments, analyze complex datasets, draw scientifically sound conclusions, and translate findings into process recommendations.
• Experience with flow cytometry-based instruments and analysis software, including sample preparation, acquisition, gating, data review, and interpretation.
• Experience operating and troubleshooting cell processing equipment and single-use systems used in cell therapy development.
• Working knowledge of process scale-up, technology transfer, process characterization, and manufacturing control strategies.
• Excellent written and verbal communication skills, with the ability to prepare high-quality technical documents and present conclusions to multidisciplinary audiences.
• Ability to work independently, manage multiple priorities, and adapt effectively in a fast-paced development environment.

Desired Skills

• Direct experience developing autologous CAR-T processes across multiple unit operations and stages of product development.
• Familiarity with available cell therapy processing platforms for cell isolation, washing, concentration, activation, expansion, formulation, and closed-system processing. Experience may include platforms such as CliniMACS Prodigy, Sepax/Sefia, LOVO/CUE, DynaCellect, G-Rex, or comparable systems.
• Advanced flow cytometry experience, including multicolor panel design, compensation or spectral unmixing, gating strategy development, and analysis of T-cell phenotype and functional markers.
• Knowledge of T-cell biology, immunology, cellular engineering, gene delivery technologies, and the relationship between process conditions and product quality attributes.
• Experience supporting GMP manufacturing, process validation, regulatory filings, deviation investigations, and interactions across clinical development stages.
• Experience with automation, digital process monitoring, data visualization, or statistical software used in bioprocess development.
• Demonstrated scientific leadership through mentoring, publications, patents, regulatory contributions, or cross-functional program leadership.

Why AstraZeneca?

Equal Opportunity

Competitive remuneration and benefits apply

• We offer a competitive Total Reward program including a market driven base salary, bonus and long-term incentive. We have a generous paid time off program and a comprehensive benefits package.
• The annual base pay for this position ranges from $116,284.00 - $174,426.00. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Closing Date