(Senior / Principal) Scientist, In Vivo Pharmacology

About the Role

Responsibilities

• Design, run, and interpret mouse studies evaluating therapeutic candidates across efficacy, pharmacology, and safety.
• Select appropriate dose, route, schedule, tissues, timepoints, endpoints, controls, and go/no-go criteria for each study.
• Perform and guide dosing by routes including IP, IV, SC, PO, intranasal, and other relevant methods based on mechanism and exposure goals.
• Perform or oversee in-life work, blood collection, necropsy, tissue collection, sample tracking, surgeries, and specialized procedures.
• Analyze PK/PD, efficacy, tolerability, biomarker, and tissue data to determine what dose, route, schedule, timepoint, or candidate to test next.
• Design and execute EEG studies where required, including surgery, electrode placement, monitoring, and electrophysiological-data processing.
• Coordinate with downstream molecular, histology, and biomarker workflows and turn each dataset into the next well-controlled experiment.

Ideal Qualifications

• Substantial hands-on experience designing and running mouse studies in biotech, pharma, academia, or a closely related setting.
• Strong translational judgment: you can design studies that test tissue exposure, target engagement, pathway modulation, phenotype, and tolerability.
• Comfort with multi-route dosing, in-life execution, necropsy, tissue and blood collection, sample tracking, and coordination with downstream assays.
• The ability to interpret PK/PD and efficacy data and make disciplined next-study or candidate decisions.
• A fast, rigorous working style with explicit hypotheses, dose rationale, endpoints, controls, and go/no-go criteria.
• You do not need prior experience with every route, procedure, or assay listed above.

Pay & Benefits

• In addition to the posted salary range, we offer generous equity options.
• Compensation will depend on the skills, experience, and scope of impact you bring. If your background, experience, or compensation needs fall outside this range, we are still open to a conversation based on the scope and impact you could bring.
• $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.
• Healthcare: We offer a broad range of medical, dental, and vision coverage options, with Capable covering 100% of the base policy.
• You will also have access to HSA, FSA, and 401K plans.
• Healthy dinners with the team are provided daily.
• We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways. Our team is already international, with members from Canada, Pakistan, Germany, Austria, Switzerland, China, India, and the United States.

Application Process

• Our process is fast, transparent, and personal. We care about getting to know the person behind the application.
• Initial application
• First phone screen
• Second phone screen
• In-person work trial in San Francisco: designed to give both sides a realistic sense of working together. Get to know the founding team!

Apply Today

Equal Opportunity