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As a Senior Principal Application Support Engineering Lead (R4), you are the senior-most operational authority for a technology team or portfolio of applications. You will lead Support Operations end-to-end, owning operational outcomes across availability, incident management, readiness, and continuous reliability improvement.
This role is both strategic and hands-on. You are accountable for:
The health, stability, and operability of production systems
The effectiveness and maturity of support operations
Shift leadership and execution during critical operational windows
Influencing engineering, product, and platform teams to prevent incidents—not just respond to them
At R4, success is measured by organizational impact, operational predictability, and the ability to scale reliability through others.
At Lilly, everything we do starts with patients. We unite caring with discovery to make life better for people around the world. Headquartered in Indianapolis, Indiana, our global team of over 50,000 employees work with urgency and purpose to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. We bring our best to this work because people depend on it. If you're driven by purpose and determined to make a meaningful difference for patients, we invite you to bring your skill and your commitment to Lilly.
At Lilly, technology is not a support function. It is how a global medicine company operates, innovates, and delivers. Lilly in Hyderabad builds the capabilities that make this possible, cloud platforms, AI systems, and automation at enterprise scale, all in service of a purpose that makes this technology work genuinely distinctive, from advancing drug discovery to enabling connected clinical trials to keeping a global medicine company running at the standard patients deserve.
Job Level: R4 – Senior Principal
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Experience: 10–14+ years
Location: Hyderabad (Onsite)
Employment Type: Full-time
Job Family: Operations / Application Support / Production Engineering / SRE-aligned Support
Technology at Lilly builds and operates mission-critical digital products and platforms that support the discovery, development, and delivery of medicines that make life better for people around the world. Our teams operate in highly regulated, high-availability environments, where operational excellence, reliability, and quality are non-negotiable.
The Software Product Engineering (SPE) organization applies a product, platform, and reliability-first mindset, ensuring that operational capabilities scale sustainably across the enterprise.
As a Senior Principal Application Support Engineering Lead (R4), you are the senior-most operational authority for a technology team or portfolio of applications. You will lead Support Operations end-to-end, owning operational outcomes across availability, incident management, readiness, and continuous reliability improvement.
This role is both strategic and hands-on. You are accountable for:
The health, stability, and operability of production systems
The effectiveness and maturity of support operations
Shift leadership and execution during critical operational windows
Influencing engineering, product, and platform teams to prevent incidents—not just respond to them
At R4, success is measured by organizational impact, operational predictability, and the ability to scale reliability through others.
At the Senior Principal (R4) level, success is defined by breadth of impact and sustained outcomes:
Be recognized as the senior operational authority for your technology area.
Demonstrate measurable, sustained improvements such as:
Reduced major incidents and repeat failures
Improved MTTR and detection times
Higher operational predictability and release confidence
Reduced dependency on manual intervention
Influence decisions across multiple teams and leaders through expertise and trust.
Scale reliability and operational excellence through systems, standards, and people, not individual effort.
Acts with enterprise-first mindset, beyond individual products or teams.
Drives accountability, clarity, and calm during high-pressure situations.
Builds trust through consistency, technical depth, and follow-through.
Raises the capability of the organization—not just personal output.
Availability to work flexible work hours is/may be required. This team will support continuous operations across two shifts and therefore, this role will require non-standard work hours, and some work on weekends and holidays. Appropriate adjustments in benefits will be provided for employees working non-standard hours where applicable.
Candidate should be open to work on different shifts - 6AM to 2PM and 2PM to 11PM when required.
At Lilly, caring is not only what we do for patients. It is how we work. We believe the people who dedicate themselves to making medicines better deserve an environment that makes their lives better too, one where they are supported, respected, and given the space to do their best work. This is not just a policy. It is who we are.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Verified company details for this employer are not available yet.
Full-time
Senior · 10+ years experience
Onsite
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