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Vaxcyte is looking for a Scientist II, Conjugation Development. The candidate’s primary responsibility will be to lead and execute experimental activities that support company’s pneumococcal conjugate vaccine program with a focus on developing a deeper understanding of the conjugation process. In parallel, the candidate will work on conjugation process development for Vaxcyte’s pipeline programs contributing to process optimization, scalability, and technical readiness for future clinical manufacturing. Specifically, this will include preparation, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. The ideal candidate will have significant laboratory experience and an excellent understanding of analytical chemistry principles. The successful candidate will be expected to design, execute, and troubleshoot experiments with minimal guidance. The candidate will also contribute when needed to a range of related areas such as analytical development and stability studies. Responsibilities will additionally include record management, data presentation at group meetings, authorship of laboratory protocols and development reports, communication with external organizations during tech transfer, and actively contributing to collaborative studies with other members of the conjugation group.
Vaxcyte is looking for a Scientist II, Conjugation Development. The candidate’s primary responsibility will be to lead and execute experimental activities that support company’s pneumococcal conjugate vaccine program with a focus on developing a deeper understanding of the conjugation process. In parallel, the candidate will work on conjugation process development for Vaxcyte’s pipeline programs contributing to process optimization, scalability, and technical readiness for future clinical manufacturing. Specifically, this will include preparation, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. The ideal candidate will have significant laboratory experience and an excellent understanding of analytical chemistry principles. The successful candidate will be expected to design, execute, and troubleshoot experiments with minimal guidance. The candidate will also contribute when needed to a range of related areas such as analytical development and stability studies. Responsibilities will additionally include record management, data presentation at group meetings, authorship of laboratory protocols and development reports, communication with external organizations during tech transfer, and actively contributing to collaborative studies with other members of the conjugation group.
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Optimize and troubleshoot multi-step syntheses of protein-polysaccharide conjugates.
Purify polysaccharides and conjugates using a variety of methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF).
Analyze polysaccharides and conjugates with a variety of analytical methods. Develop new laboratory workflows and analyses beyond established procedures when appropriate.
Advise team members on experimental design, interpretation of results, and troubleshooting.
Model and train team members on best practices for adherence to protocols and data management.
Serve as a subject matter expert during tech transfer of conjugation processes to contract manufacturing organizations.
Maintain highly organized records to enable optimization and assessment of reproducibility.
Attend team meetings ready to provide updates on conjugation development progress.
Clinical-stage vaccine company developing next-generation conjugate vaccines targeting bacterial infections with high unmet medical need.
Visit company websiteUSD 146000-171000 / year
Senior · 10+ years experience
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