Scientist, Computational Biology

Conduct tertiary analyses of large-scale Perturb-seq, single-cell sequencing, multi-omic, and functional genomics datasets to identify functional relationships between genes, regulatory programs, and cellular phenotypes.

Depending on your track, this includes work such as e.g. guide assignment, perturbation-effect estimation, and interaction modeling for pooled CRISPR screens, or trajectory and cell-state analysis of microglial state transitions in neurodegeneration.

Partner with experimental teams on iterative study design, analysis, interpretation, and validation, discovering computational insights that translate into testable biological hypotheses.

Work closely with bioinformatics and data infrastructure teams to define clean handoffs from primary and secondary analysis into exploratory and mechanistic modeling.

Contribute to Arc's Virtual Cell and Alzheimer's Disease Initiatives by generating, analyzing, visualizing, and interpreting datasets that fuel predictive models.

Develop reusable analysis notebooks, dashboards, software tools, benchmarks, and data resources that allow Arc scientists to explore complex datasets effectively.

Present findings to internal stakeholders, and contribute to preprints or open-source projects when the opportunity arises or as needed.

Mentor colleagues and interns and contribute to a collaborative, intellectually rigorous team environment.

Background in cell identity, reprogramming, RNA biology, cell engineering, neurobiology, immunology, cancer biology, or complex disease genetics.

Familiarity with dimensionality reduction and gene module analysis techniques in the context of single-cell biology.

Experience in a startup, technology center, research institute, or other highly collaborative environment where scientific direction and technical execution are tightly coupled.

The base salary range for this position is $135,000 to $186,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.