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Founded in 2013 and based in San Diego, California, Arcturus Therapeutics Holdings Inc. (Nasdaq: ARCT) is a global, late-stage clinical mRNA medicines and vaccines company with enabling technologies: (i) LUNAR® lipid-mediated delivery, (ii) STARR™ mRNA Technology (samRNA) and (iii) mRNA drug substance along with drug product manufacturing expertise. Arcturus’ diverse pipeline of RNA therapeutic and vaccine candidates includes mRNA vaccine programs for SARS-CoV-2 (COVID-19) and Influenza, and other programs to potentially treat ornithine transcarbamylase (OTC) deficiency, and cystic fibrosis, along with partnered programs including glycogen storage disease type III, and hepatitis B virus. Arcturus’ versatile RNA therapeutics platforms can be applied toward multiple types of nucleic acid medicines including messenger RNA, small interfering RNA, replicon RNA, antisense RNA, microRNA, DNA, and gene editing therapeutics. Arcturus’ technologies are covered by its extensive patent portfolio (patents and patent applications issued in the U.S., Europe, Japan, China and other countries). Arcturus’ commitment to the development of novel RNA therapeutics has led to collaborations including, amongst others, Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, Ultragenyx Pharmaceutical, Inc., and the Cystic Fibrosis Foundation.
Arcturus Therapeutics is presently recruiting outstanding candidates with experience in the field of mRNA technologies and nanoparticle sciences. Our corporate culture is dynamic, diverse, and creative. We value collaboration and teamwork. We seek individuals to join us with a genuine passion for the science behind helping to cure disease and improve the lives of patients.
We are seeking a temporary Research Associate I/II to join our Formulation Team at our Headquarters in San Diego, CA.
In this role, you will support scale-up, manufacturing, and characterization of lipid nanoparticle-based nucleic acid formulations to support our emerging research pipeline. Our ideal candidate will bring a willingness to learn and contribute to our formulation production and purification processes.
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San Diego, USA
San Diego, USA
San Diego, USA
San Diego, USA
San Diego, USA
Develop nucleic based formulations including complex nanoparticle formulations to support in vitro and in vivo studies for different programs.
Conduct process development of mRNA-LNP drug product to enable successful production of large-scale drug product in internal and external manufacturing sites.
Perform process-related investigations, identify root causes of process/manufacturing discrepancies, evaluate systems for trends and adverse findings, and implement appropriate steps to ensure process robustness.
Perform formulation stability studies, contact material compatibility, in-use compatibility study, and accelerated stability studies.
Maintain proper documentation of all experimental procedures and results, including batch records, protocols, Standard Operating Procedures (SOPs) and other manufacturing related documentations.
Prepare technical reports and presentations which summarize procedures, study results, and data interpretation as needed.
Deliver high quality results in an accurate and a time sensitive manner
Perform other activities as needed.
2+ years of relevant formulation development experience in a life science, pharmaceutical company, or academic lab setting. Experience with nucleic acid-based and/or lipid nanoparticle formulation development is a major plus.
Hands on experience working with liquid, frozen, and/or lyophilized dosage forms and related biophysical and chemical analytical methods such as dynamic light scattering.
Experience with TFF (Tangential Flow Filtration), dead-end filtration, and/or fill/finish is a plus.
Record experiments and results in laboratory notebooks (including all electronic systems) in accordance with lab procedures in sufficient detail that co-worker can repeat experiment and interpret results in a timely manner
Attention to details, ability to think ahead and strong communication skills
Self-motivated team player excels in a highly innovative, collaborative, and fast-paced environment.
Bachelor's or Master’s degree in Chemistry, Pharmaceutical Sciences, Biochemistry, Chemical Engineering, Bioengineering or other related science field
Public biotechnology company developing messenger RNA medicines and vaccines for rare liver, respiratory, and infectious diseases.
Visit company websiteJobs and hiring trendsUSD 34-52.39 hourly / hour
Temporary
Entry · 2+ years experience
Onsite
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