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Process Development Scientist, Biocatalysis

Cascade Bio

Denver, USA

Full-time

Mid · 4+ years experience

Onsite

USD 110000-150000 yearly / year

Discovered 1 weeks ago

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Denver, CO (on-site) Type: Full-time
Job Description: Cascade Biocatalysts is building the next generation of industrial biocatalysts and is seeking a hands-on Process Development Scientist, Biocatalysis to join and lead our biocatalytic process development, intensification, and scale-up efforts.
This is a foundational role at Cascade Bio. You will be the person who builds our process development function, setting technical direction, establishing SOPs and standards, and owning the path from bench-scale proof of concept to a process that works at commercial scale. You will work directly with the founding team, with ownership over outcomes and the opportunity to shape not just the science but the culture and direction of the company.
The right candidate is a subject matter expert on commercial biocatalysis and is as comfortable running reactions at the bench as they are thinking about cost per kilogram and scale-up implications. The ideal candidate comes from a biocatalysis-focused company, CDMO, or industrial process chemistry group, and is now ready to bring that instinct and experience to a place where their work will have direct and visible impact.

Own biocatalytic process development end-to-end, from initial hits to optimized ready to scale processes
Run and optimize enzymatic reactions, driving process intensification by improving space-time yield, reducing enzyme loading, extending catalyst lifetime, and lowering overall process costs
Collaborate with our enzyme immobilization team to evaluate and implement biocatalyst formats
Evaluate and implement new equipment and process analytical technology solutions
Lead and grow a small process development team over time, mentoring junior scientists while maintaining a technical culture and standards
Build and maintain techno-economic models tracking key process metrics: E-factor, PMI, catalyst cost contribution, and downstream processing implications
Interface with protein engineering efforts, translating process bottlenecks into enzyme engineering targets and back-integrating improved variants
Contribute broadly across the organization: at this stage of the company, the most impactful team members bring their expertise to problems beyond their core scope

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