Principal Research Associate at Deepgenomics — Cambridge, USA | Base Career

Role Overview

• Design, optimise and execute robust cell-based assays, to support compound screens and lead optimisation.

• Culture, maintain and transfect a variety of mammalian cell lines, such as immortalized cell lines, primary cells and co-culture systems, and onboard new cell types and systems to enable drug discovery.

• Examine important molecular and functional endpoints in vitro, including RNA and protein readouts, to better understand our molecules in our internal therapeutic pipeline.

• Perform standard molecular biology techniques (e.g. PCR, qPCR, Jess/Leo Automated Westerns, ELISA, Western blot, etc.).

• Collaborate with a cross-functional team in a dynamic, matrixed environment to achieve shared company deadlines, and communicate experimental design and findings with colleagues and project teams.

• Clearly document experiments, standard operating procedures (SOPs) and data in an electronic lab notebook (ELN).

• BS or MS in Biology, Molecular Biology, Genomics, Biochemistry or a related field with 4+ years of relevant pharmaceutical or biotechnology experience.

• Strong hands-on experience growing, maintaining and transfecting mammalian cell lines.

• Good understanding of molecular and cell biology.

• Experienced in design and execution of molecular and cellular assays, including documentation in an electronic lab notebook (ELN).

• Excellent communication, organizational skills and a willingness to learn.

• Ability to prioritise and drive work independently in a fast-paced, technical and data-rich environment.

• Hands-on experience using primary hepatocytes is strongly preferred.

• Proficiency in automated Western blotting methods, such as the Jess/Leo platforms.

• Flow cytometric experience is a plus.

• Experience with high-throughput liquid handlers (e.g. Beckman Echo, Agilent Bravo and/or Hamilton STAR/STAR V).

• Next-generation sequencing library preparation, e.g. amplicon sequencing.

• Past experience with RNA editing and/or RNA oligonucleotides.

• Demonstrated experience working in cross-functional teams.

• A collaborative and innovative environment at the frontier of computational biology, machine learning, and drug discovery.

• Highly competitive compensation, including meaningful stock ownership.

• Comprehensive benefits - including health, vision, and dental coverage for employees and families, employee and family assistance program.

Full Job Posting

About The Role

Design, optimise and execute robust cell-based assays, to support compound screens and lead optimisation.
Culture, maintain and transfect a variety of mammalian cell lines, such as immortalized cell lines, primary cells and co-culture systems, and onboard new cell types and systems to enable drug discovery.
Examine important molecular and functional endpoints in vitro, including RNA and protein readouts, to better understand our molecules in our internal therapeutic pipeline.
Perform standard molecular biology techniques (e.g. PCR, qPCR, Jess/Leo Automated Westerns, ELISA, Western blot, etc.).
Collaborate with a cross-functional team in a dynamic, matrixed environment to achieve shared company deadlines, and communicate experimental design and findings with colleagues and project teams.
Clearly document experiments, standard operating procedures (SOPs) and data in an electronic lab notebook (ELN).
BS or MS in Biology, Molecular Biology, Genomics, Biochemistry or a related field with 4+ years of relevant pharmaceutical or biotechnology experience.
Strong hands-on experience growing, maintaining and transfecting mammalian cell lines.
Good understanding of molecular and cell biology.
Experienced in design and execution of molecular and cellular assays, including documentation in an electronic lab notebook (ELN).
Excellent communication, organizational skills and a willingness to learn.
Ability to prioritise and drive work independently in a fast-paced, technical and data-rich environment.
Hands-on experience using primary hepatocytes is strongly preferred.
Proficiency in automated Western blotting methods, such as the Jess/Leo platforms.
Flow cytometric experience is a plus.
Experience with high-throughput liquid handlers (e.g. Beckman Echo, Agilent Bravo and/or Hamilton STAR/STAR V).
Next-generation sequencing library preparation, e.g. amplicon sequencing.
Past experience with RNA editing and/or RNA oligonucleotides.
Demonstrated experience working in cross-functional teams.
A collaborative and innovative environment at the frontier of computational biology, machine learning, and drug discovery.
Highly competitive compensation, including meaningful stock ownership.
Comprehensive benefits - including health, vision, and dental coverage for employees and families, employee and family assistance program.
Flexible work environment - including flexible hours, extended long weekends, holiday shutdown, unlimited personal days.
Maternity and parental leave top-up coverage, as well as new parent paid time off.
Focus on learning and growth for all employees - learning and development budget & lunch and learns.
Facilities located in the heart of Toronto - the epicenter of machine learning and AI research and development, and in Kendall Square, Cambridge, Mass. - a global center of biotechnology and life sciences.

Principal Research Associate

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