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mRNA Process Development Senior Scientist
Eurofins
Boston, USA
Full-time
Mid-Senior
Onsite
Discovered 3 weeks ago
mRNA process developmentProcess characterization and validationTechnology transferPlasmid DNA fermentationBioreactors and fermentersIn vitro transcription (IVT)
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mRNA process developmentProcess characterization and validationTechnology transfer
Role Overview
Join the mRNA process development team and contribute to process characterization and technology transfer for clinical development programs.
The role requires knowledge of GMP regulatory expectations for biologic gene-edited material.
Direct mRNA process development experience is strongly preferred.
Key Skills for This Role
mRNA process developmentProcess characterization and validationTechnology transferPlasmid DNA fermentationBioreactors and fermentersIn vitro transcription (IVT)
Full Job Posting
Role Overview
Join the mRNA process development team and contribute to process characterization and technology transfer for clinical development programs.
The role requires knowledge of GMP regulatory expectations for biologic gene-edited material.
Direct mRNA process development experience is strongly preferred.
Process Development Responsibilities
- Design, execute, and analyze experiments to develop and optimize mRNA process characterization techniques.
- Evaluate process performance and identify opportunities for productivity improvements.
- Support transition of development-stage processes toward GMP-compliant manufacturing.
- Develop scalable plasmid DNA production processes using fermentation systems.
- Operate and troubleshoot bioreactors and fermenters.
- Develop, optimize, and troubleshoot IVT process development activities.
- Develop and troubleshoot chromatography purification processes using Cytiva AKTA Avant.
- Use Agilent 1260 HPLC/UHPLC systems for nucleic acid analysis, impurity profiling, quantitation, and process characterization.
- Analyze data for process optimization, troubleshooting, and technology transfer.
- Author and review GMP-relevant reports, protocols, batch records, and development summaries.
- Present findings to management and project teams and uphold laboratory safety standards.
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