Director, Enterprise Architecture

• 10 or more years of experience in architecture, engineering, or related technology leadership roles, including a meaningful portion in biotech, pharmaceutical, life sciences, or another highly regulated environment.

• Demonstrated ability to architect and ship production systems at enterprise scale, with continued hands-on fluency in code, platform patterns, and technical design tradeoffs.

• Working knowledge of GxP validated systems and the practical application of 21 CFR Part 11, EU Annex 11, and GAMP 5 to data platforms, integration patterns, and AI-enabled systems.

• Experience with regulated data domains such as clinical, regulatory, safety and pharmacovigilance, quality, manufacturing and supply, commercial, HCP, HCO, or patient-level data.

• Knowledge of privacy, transparency, data governance, and AI governance expectations, including lineage, cataloging, classification, stewardship, data quality controls, model risk classification, and third-party AI assessment.

• Experience defining reference architectures, technical standards, reusable patterns, and architecture governance processes for enterprise-scale data, AI, integration, or platform environments

· Experience with modern data, AI, and platform technologies such as Snowflake, dbt, Fivetran, Astronomer, Monte Carlo, AWS, Collibra, Microsoft 365, Copilot, or comparable tools and platforms.

· Experience with AI governance, responsible AI controls, agent and tool authorization patterns, model risk classification, or vendor AI assessment.

· Experience building platform, cloud, or software engineering capabilities in financial services, complex manufacturing, large-scale technology platforms, or other regulated environments.

· Prior people leadership experience, including leading architects or senior technical contributors.

· Minimal travel expected.

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.