Associate Scientist, Protein Sciences

will include, but are not limited to, the following:

• Be a contributor to the discovery and development of antibody therapeutics for oncology and immune oncology for novel targets.
• Support recombinant protein and bi- and multi-specific antibody discovery plans (immunogen design, assay development, screening, and functional characterization methods)
• Support biological discovery through different platforms of protein and antibody discoveries.
• Responsible for various target projects to execute protein production , purification and antibody discovery/optimization in various platforms . Specifically, Produce and purify novel and logic-gated alternative format antibodies using mammalian expression systems utilizing an assortment of molecular biology & biochemical techniques ( i.e. AKTA systems and other chromatographic columns).
• Generate target over-expressing cell lines for antibody discovery work .
• Develop strategies to express, purify, and analyze proteins for novel tumor targets expressed in mammalian cells.
• Perform purification using AKTA/HPLC systems and maintain equipment.
• Conduct antibody characterization of antibodies including binding affinity and binding kinetics through Octet/ Biacore , epitope binning/mapping, and functional assays.
• Troubleshoot experimental issues with guidance; contribute to process and assay transfers.
• Mentor lower-level colleagues and assist in scientific optimization & development.
• Analyze data, interpret results, identify problems, and develop trouble-shooting plans
• Maintain accurate documentation and follow laboratory safety procedures.
• Knowledge of the biologics drug discovery process and representation of the protein science function at project team meetings.
• Compliances with data management, laboratory notebook policy, and laboratory safety.

Please note the roles and responsibilities for the position include but are not limited to the above

Req uired Qualifications and Skills:

• PhD in biological sciences or a related field, including candidates who are completing or have recently completed their PhD, with demonstrated experience in relevant research areas; or MS with 5+ years; or BS with 8+ years of relevant experience in the biopharmaceutical industry or a closely related scientific discipline, preferably in a fast-paced biotech or startup environment.
• Experience in molecular biology or/and biochemistry, including gene manipulation, subcloning, expression vector modifications, and protein expressions in HEK & CHO cell systems
• Extensive experience in human protein and antibody purification techniques, including affinity chromatography, Mixed mode chromatography, Hydrophobic Interaction C hromatography (HIC), I on E xchange C hromatography (IEX), and S ize E xclusion C hromatography (SEC). Proficiency in operating and troubleshooting modern chromatography hardware and software, such as Cytiva AKTA systems and Agilent HPLC and UPLC.

• Experience in developing and optimizing recombinant proteins and bi- and multi-specific antibody formats across multiple parameters.
• Antibody drug discovery experience for immune oncology in biopharmaceutical industry is a plus.
• Ability to independently manage projects and deliver results on stringent timelines with high quality is plus

One of our top priorities is to maintain the health and wellbeing of our employees and their families.

To achieve this goal, we offer comprehensive benefits.

• Medical, dental and vision insurance for employee and dependents

• STD, LTD, Basic Life and AD&D Insurance, Supplemental Life
• 401(k) Plan
• 120 hours of Paid Time Off
• 5 sick days per year
• 11 holidays

• Annual bonus program
• New hire stock options

OBT is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status.

All qualified applicants will receive consideration for employment.

One of our top priorities is to maintain the health and wellbeing of our employees and their families.

To achieve this goal, we offer comprehensive benefits